About This Peptide
Dihexa (PNB-0408) is an experimental, orally active peptide derivative that functions as a potent neurogenic and synaptogenic compound.
It was originally developed by researchers at Washington State University as a candidate drug to repair brain tissue and reverse cognitive decline associated with neurodegenerative conditions like Alzheimer’s disease.
Primary Mechanism of Action Dihexa acts as a high-affinity ligand for HGF (Hepatocyte Growth Factor) and its receptor, c-Met:
- Activates the HGF/c-Met Pathway: By binding to HGF, Dihexa dramatically potentiates its activity at the c-Met receptor, triggering intracellular signaling cascades involved in cell survival and growth.
- Promotes Spinogenesis & Synaptogenesis: It stimulates the rapid formation of new dendritic spines and synaptic connections between neurons in the brain, specifically in regions like the hippocampus, which controls memory and learning.
- Enhances Neuroplasticity: Research models indicate it can repair damaged neural networks, helping restore cognitive function, memory formation, and processing speed.
Is This Right For You?
Patients often come to us interested in this treatment for sleeping better, easing anxiety, or sharpening focus and memory. If that sounds like what you’re looking for, our provider can walk you through whether it’s a good fit for your goals during your consultation.
Ordering & Shipping
New Patient Package. This price includes your initial in-person consultation, physical consultation with our licensed provider at New Jersey Trim Clinic, and the product itself. After checkout, you will receive an order confirmation email thanking you for your order. Our team will then contact you by text, phone, or email to schedule your provider appointment in-person or telehealth. Medication will be ordered and shipped 2-day air ($15 charge) to you after our provider confirms this treatment is appropriate for you. If our provider determines this product is not appropriate for you, a 100% refund will be issued.
For use only under the guidance of a licensed medical provider. Individual results vary. This description is for informational purposes only and does not constitute medical advice.






