About This Peptide
Tesamorelin is a synthetic 44-amino acid peptide analog of endogenous Growth Hormone-Releasing Hormone (GHRH). It features a trans-3-hexenoic acid modification at its N-terminal end, which makes it substantially more resistant to enzymatic degradation (by dipeptidyl peptidase IV) than natural GHRH. By binding selectively to GHRH receptors on the anterior pituitary gland, Tesamorelin stimulates the body to synthesize and secrete its own natural Growth Hormone (GH) in a physiological, pulsatile fashion.
Primary Actions in the Body
- Targeted Visceral Fat Reduction (Lipolysis): Tesamorelin is uniquely potent at reducing visceral adipose tissue (VAT), the deep, dangerous abdominal fat surrounding internal organs, without significantly reducing subcutaneous fat. It triggers lipolysis by binding directly to growth hormone receptors on adipocytes and downregulating fat storage pathways.
- Downstream IGF-1 Elevation: As circulating growth hormone pulses increase, GH signals the liver to produce Insulin-like Growth Factor 1 (IGF-1). IGF-1 mediates cellular growth, tissue repair, muscle protein synthesis, and metabolic homeostasis.
- Reduction of Hepatic Fat (Liver Steatosis): Clinical trials show that Tesamorelin significantly reduces liver fat accumulation (hepatic steatosis) in patients with metabolic dysfunction, supporting overall metabolic health and liver enzyme profiles.
- Preservation of Endogenous GH Feedback: Unlike direct exogenous human growth hormone (hGH) injections, which can shut down native pituitary function, Tesamorelin stimulates natural pulsatile GH release, preserving the body’s somatostatin negative feedback loop and avoiding severe hormone suppression.
Is This Right For You?
Patients often come to us interested in this treatment for building lean muscle, recovering faster, or supporting healthy aging, or losing stubborn fat or supporting weight loss. If that sounds like what you’re looking for, our provider can walk you through whether it’s a good fit for your goals during your consultation.
Ordering & Shipping
New Patient Package. This price includes your initial in-person consultation, physical consultation with our licensed provider at New Jersey Trim Clinic, and the product itself. After checkout, you will receive an order confirmation email thanking you for your order. Our team will then contact you by text, phone, or email to schedule your provider appointment in-person or telehealth. Medication will be ordered and shipped 2-day air ($15 charge) to you after our provider confirms this treatment is appropriate for you. If our provider determines this product is not appropriate for you, a 100% refund will be issued.
For use only under the guidance of a licensed medical provider. Individual results vary. This description is for informational purposes only and does not constitute medical advice.
