About This Peptide
KPV (Lysine-Proline-Valine) is a synthetic tripeptide representing the C-terminal amino acid sequence of alpha-melanocyte-stimulating hormone (alpha-MSH). It retains the potent anti-inflammatory, mucosal protective, and antimicrobial properties of the full alpha-MSH hormone, but without stimulating pigment cells (melanocytes) or causing skin darkening.
Primary Actions in the Body
- Downregulation of NF-kB (Potent Anti-Inflammatory): KPV enters epithelial and immune cells to inhibit the translocation of Nuclear Factor kappa B (NF-kB) into the cell nucleus. By shutting down this core inflammatory pathway, it sharply reduces the production of pro-inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6.
- Gastrointestinal & Mucosal Repair: KPV is heavily studied in inflammatory bowel disease (IBD) models, including ulcerative colitis and Crohn’s disease. It calms intestinal lining inflammation, reduces tissue edema, and supports epithelial barrier restoration (“leaky gut”).
- Broad-Spectrum Antimicrobial & Anti-Fungal Activity: Research indicates that KPV exerts direct antimicrobial effects, particularly against fungal pathogens like Candida albicans, by disrupting microbial cell structures and inhibiting pathogen growth in mucosal tissues.
- Dermal Health & Wound Healing: When applied topically or administered systematically, KPV reduces skin inflammatory conditions like eczema, psoriasis, rosacea, and contact dermatitis while promoting cleaner collagen reorganization to minimize scar formation.
Is This Right For You?
Patients often come to us interested in this treatment for healing an injury, easing joint pain, or recovering from a strain. If that sounds like what you’re looking for, our provider can walk you through whether it’s a good fit for your goals during your consultation.
Ordering & Shipping
Refill for existing patients. After checkout, you will receive an order confirmation email thanking you for your order. Medication will be shipped 2-day air ($15.00) only after our provider confirms this refill treatment is appropriate for you. If our provider determines this product is not appropriate for you, a 100% refund will be issued.
For use only under the guidance of a licensed medical provider. Individual results vary. This description is for informational purposes only and does not constitute medical advice.
